The rising tide of dementia worldwide

نویسندگان

Eric B Larson

Kenneth M Langa

چکیده

430 www.thelancet.com Vol 372 August 9, 2008 in the general population, it is diffi cult to exclude chance as an explanation for their fi ndings. In today’s study, Vestergaard and colleagues tested the hypothesis that febrile seizures are associated with an increased risk of death, by examining mortality data from a cohort of more than 1·6 million children, including over 55 000 children with febrile seizures and over 8000 deaths. They noted that in children who had a febrile seizure, there was an increased risk of death in the 2 years after the fi rst febrile seizure, but that the absolute risk of death was still very low. In a nested case-control study, they attempted to fi nd more clinical information than is usually available in registry data, through review of medical records. They report that the increased risk of death after febrile seizure was seen only in children with complex febrile seizures and in those with underlying neurological abnormalities. Vestergaard and colleagues’ study again seems to refute, for infants and children who have simple febrile seizures, the idea of a shared cause between febrile seizures and sudden death. Similar to previous studies, most recently that of Kinney and colleagues, the new study suggests there is a subset of children with febrile seizures—notably those with complex features and underlying neurological abnormalities—that might warrant closer attention and follow-up.

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